Publications
 
DNA & RNA
2014 - "Compositions and methods for custom site-specific DNA recombinases", JC Lamb and AG Evdokimov, US20140193915
2014 - "COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA", James A. Baum, Allen T. Christian, Artem Evdokimov, Farhad Moshiri, Lisa Marie Weaver, Haitao Zhang US 20140271559.
2003-2006 - "Aminoglycoside-arginine conjugates as anti-HIV drug candidates", Lapidot, A., Evdokimov A.G. & Litovchick A.
European Patent #1140958, granted in 2006; U.S. Patent granted in 2003; Israeli Patent #127773, granted in 2003.
[PDF]
2000 - "Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection", Cabrera C., Gutierrez A.,Blanco J., Barretina J., Litovchick A., Lapidot A., Evdokimov A.G., Clotet B., Este J. AIDS Res. & Human Retrovir. 2000, 16, 627-634.
[LINK][PDF]
2000 - "Aminoglycoside-Arginine conjugates - synthesis, characterization and antiviral properties", Litovchick A., Evdokimov A.G. & Lapidot A., Biochemistry 2000, 39, 2838-2852.
[LINK][PDF]
1998 - "Arginine-Aminoglycoside conjugates that bind to TAR RNA in vitro", Litovchick A., Evdokimov A.G. & Lapidot A., FEBS Lett. 1998, 445(1), 73-77.
[LINK][PDF]

Anti-HIV research
2003-2006 - "Aminoglycoside-arginine conjugates as anti-HIV drug candidates", Lapidot, A., Evdokimov A.G. & Litovchick A.
European Patent #1140958, granted in 2006; U.S. Patent granted in 2003; Israeli Patent #127773, granted in 2003.
[PDF]
2000 - "Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection", Cabrera C., Gutierrez A.,Blanco J., Barretina J., Litovchick A., Lapidot A., Evdokimov A.G., Clotet B., Este J. AIDS Res. & Human Retrovir. 2000, 16, 627-634.
[LINK][PDF]
2000 - "Aminoglycoside-Arginine conjugates - synthesis, characterization and antiviral properties", Litovchick A., Evdokimov A.G. & Lapidot A., Biochemistry 2000, 39, 2838-2852.
[LINK][PDF]
1998 - "Arginine-Aminoglycoside conjugates that bind to TAR RNA in vitro", Litovchick A., Evdokimov A.G. & Lapidot A., FEBS Lett. 1998, 445(1), 73-77.
[LINK][PDF]

Anti-bacterial research; type III secretion and flagellum assembly
2012 - "Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance.", Schumacher M.A., Min J., Link T.M., Guan Z., Xu W., Ahn Y.H., Soderblom E.J., Kurie J.M., Evdokimov A., Moseley M.A., Lewis K., Brennan R.G. Cell Rep. 27:2(3), 518-525.
[LINK][PDF]
2010 - "Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.", Han, S., Zaniewski, R.P., Marr, E.S., Lacey, B.M., Tomaras, A.P., Evdokimov, A., Miller, J.R., Shanmugasundaram, V., Proc.Natl.Acad.Sci.USA 107: 22002-22007
[LINK][PDF]
2009 - "New kinase regulation mechanism found in HipBA: a bacterial persistence switch", A. Evdokimov, I. Voznesensky, K. Fennell, M. Anderson, J. F. Smith and D. A. Fisher, Acta Cryst, D65: 875-879.
[LINK][PDF]
2009 - "Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase", Igor Mochalkin, J. Richard Miller, Artem Evdokimov, Sandra Lightle, Chunhong Yan, Charles Ken Stover, and Grover L. Waldrop, Protein Science, 17(10): 1706-1718.
[LINK][PDF]
2008 - "Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.",Artem G. Evdokimov, Marlene Mekel, Kim Hutchings, Lakshmi Narasimhan, Tod Holler, Teresa McGrath, Bryan Beattie, Eric Fauman, Chunhong Yan, Holly Heaslet, Barry Finzel, Jeffrey Ohren, Patrick McConnell, Timothy Braden, Fang Sun, Cindy Spessard, Craig Banotai, Loola Al-Kassim, Weijun Ma, Paul Wengender, Denis Kole, Norman Garceau, Peter Toogood and Jia Liu . Journal of Structural Biology, 162(1):152-169.
[ LINK] [PDF]
2007 - "Structural biology approaches to antibacterial drug discovery", Tod P Holler, Artem G Evdokimov, Lakshmi Narasimhan; Expert Opinion on Drug Discovery Vol. 2, No. 8, 1085-1101
[LINK] [PDF]
2007 - "Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors", Artem G. Evdokimov, Matthew Pokross, Richard L. Walter, Marlene Mekel, Bobby L. Barnett, Jack Amburgey, William L. Seibel, Shari J. Soper, Jane F. Djung, Neil Fairweather, Conrad Diven, Vinit Rastogi, Leo Grinius, Charles Klanke, Richard Siehnel, Tracy Twinem, Ryan Andrews, Alan Curnow Proteins: Structure, Function, and Bioinformatics. 66(3), 538-546.
[LINK] [PDF]
2004 - "The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague", Derewenda U., Mateja A., Devedjiev Y., Routzahn K.M., Evdokimov A.G., Derewenda Z.S., Waugh D.S., Structure (Camb). 2004 12(2), 301-6.
[LINK][PDF]
2004 - "Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion", Evdokimov A.G., Phan J., Tropea J.E., Routzahn K.M., Peters H.K., Pokross M., Waugh D.S., Nature Structural Biology 2003, 10, 789-93.
[LINK][PDF]
2002 - "Crystal structure of the Yersinia pestis GTPase activator YopE.", Evdokimov A.G., Tropea J., Routzahn K., Waugh D.S., Protein Science, 2002, 11(2), 401-408.
[LINK][PDF]
2002 - "Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis", Evdokimov A.G., Tropea J., Routzahn K., Waugh D.S., Acta Cryst. D, 2002, 58, 398-406.
[LINK][PDF]
2001 - "Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.", Evdokimov A.G., Anderson D.E., Routzahn, K., Waugh D.S., J. Mol. Biol. 2001, 312(4), 807-821.
[LINK][PDF]
2001 - "Crystal structure of the N-terminal domain of Yersinia pestis YopH at 2.0 A resolution", Evdokimov A.G., Tropea J., Routzahn K., Copeland, T. Waugh D.S., Acta Cryst. D, 2001, 57, 793-799.
[LINK][PDF]
2000 - "Purification, crystallization and preliminary crystallographic analysis of YopM - a leucine rich effector protein of the Bubonic Plague", Evdokimov A.G., Anderson D.E., Routzahn, K., Waugh D.S., Acta Cryst. 2000, D56, 1676-1679.
[LINK][PDF]

Carbohydrate structure and chemistry
2001 - "Structural Basis for Oligosaccharide Recognition by Pyrococcus furiosus Maltodextrin-Binding Protein", Evdokimov A.G., Anderson D.E., Routzahn K., and Waugh D.S., J. Mol. Biol. 2001, 305(4), 891-904.
[LINK][PDF]
2001 - "Structures of Furanosides: Geometrical Analysis of Low Temperature X-ray and Neutron Crystal Structures of the Five Crystalline Methyl Pentofuranosides", Evdokimov A.G., Kalb (Gilboa) A.J., Koetzle T.F., Klooster W.T., Schultz A.J., Mason S.A., Albinati A., and Frolow F., Acta Cryst. B 2001, 57, 213-220.
[LINK][PDF]
2000 - "Structures of furanosides: A Study of the conformational space of Methyl alpha-D-lyxofuranoside by density functional methods", Evdokimov A.G., Martin J.M.L., and Kalb (Gilboa) A.J., J. Phys. Chem. A. 2000, 104, 5291-5297.
[LINK][PDF]
1999 - "Structures of furanosides: density functional calculations and high resolution X-ray and neutron diffraction crystal structures", Evdokimov A.G., Kalb (Gilboa) A.J., Koetzle T.F., Klooster W.T., and Martin J.M.L., J. Phys. Chem A, 1999 vol. 103(6) 744-753.
[LINK][PDF]
1997 - "3-deoxy, methyl alpha-D-arabino hexopyranoside", Evdokimov A.G. and Frolow F., Acta Cryst. C, 1997, C53, 264-266.
[LINK][PDF]
1996 - "Methyl alpha-D-Lyxopyranoside", Evdokimov A.G. and Frolow F., Acta Cryst. C, 1996, C52, 3218-3219.
[LINK][PDF]

Farnesyl diphosphate synthase
2008 - "Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.", Deprčle S., Kashemirov B.A., Hogan J.M., Ebetino F.H., Barnett B.L., Evdokimov A., McKenna C.E. Bioorg Med Chem Lett. 18(9), 2878-82
[LINK][PDF]

Insect control
2014 - "Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals.", Artem G. Evdokimov, Farhad Moshiri, Eric J. Sturman, Timothy J. Rydel, Meiying Zheng, Jeffrey W. Seale and Sonya Franklin. Protein Science, 23:11, 1491-1497
2013 - "Insect Inhibitory Toxin Family Active Against Hemipteran and/or Lepidopteran Insects", David J. Bowen, Catherine Chay, Artem Evdokimov, Megan N. Schroder, Rachael N. Slightom, Uma Sukuru, Nengbing Tao, Andrew M. Wollacott, US 20130097735

Kinases
2006 - "The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).", Sabat M, Vanrens JC, Laufersweiler MJ, Brugel TA, Maier J, Golebiowski A, De B, Easwaran V, Hsieh LC, Walter RL, Mekel MJ, Evdokimov A, Janusz MJ., Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7
[LINK][PDF]

Method development
2010 - "Multiplex enzyme assays and inhibitor screening by mass spectrometry.", Rathore R, Pribil P, Corr JJ, Seibel WL, Evdokimov A, Greis KD., J Biomol Screen. Sep;15(8):1001-7.
2006 - "Structural basis for the fast maturation of Arthropoda green fluorescent protein.", Evdokimov A.G., Pokross M.E., Egorov N.S., Zaraisky A.G., Yampolsky I.V., Merzlyak E.M., Shkoporov A.N., Sander I., Lukyanov K.A., Chudakov D.M., EMBO Rep. 2006, 7(10), 1006-12.
[LINK][PDF]
2006 - "Rescuing low-quality crystals.", Evdokimov A.G. News Dimensions, Issue 3, 2006
[LINK][PDF]
2006 - "MALDI-TOF MS as a Label-free Approach to Rapid Inhibitor Screening", Greis, K.D., Zhou, S., Burt, T.M., Carr, A., Dolan, E., Easwaran, V., Evdokimov, A.G., Kawamoto, R., Roesgen, J., & Davis, G.F., J. Am. Soc. Mass Spectrom. 2006, 17(6), 815-22.
[LINK][PDF]
2003 - "Tobacco etch virus proteinase: crystal structure of the active enzyme and its inactive mutant", Zhdanov A.S., Phan J., Evdokimov A.G., Tropea J.E., Kapust R.B., Li M., Wlodawer A., Waugh D.S., Bioorg Khim. 2003, 29(5), 457-60.
2002 - "Structural basis for the substrate specificity of tobacco etch virus protease"., Phan J, Zdanov A, Evdokimov A.G., Tropea J.E., Peters H.K. 3rd, Kapust R.B., Li M., Wlodawer A., Waugh D.S., J Biol Chem. 2002, 277(52), 50564-72.
[LINK][PDF]
2002 - "Differential effects of short affinity tags on the crystallization of Pyrococcus furiosus maltodextrin-binding protein", Bucher M.H., Evdokimov A.G., Waugh D.S., Acta Cryst. D, 2002, 58, 392-397.
[LINK][PDF]
1995 - "Crystallization of a protein by microseeding, after establishing its phase diagram",Korkhin Y. and Evdokimov A.G., Douglas Instruments application notes, report by P. S. Stewart.
[LINK][PDF]

Miscellaneous enzymes
2012 - "The enzymology of alanine aminotransferase (AlaAT) isoforms from Hordeum vulgare and other organisms, and the HvAlaAT crystal structure.", Duff S.M., Rydel T.J., McClerren A.L., Zhang W., Li J.Y., Sturman E.J., Halls C., Chen S., Zeng J., Peng J., Kretzler C.N., Evdokimov A. Arch. Biochem. Biophys. 528(1), 90-101.
[LINK][PDF]
2012 - "Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.", Dounay AB, Anderson M, Bechle BM, Campbell BM, Claffey MM, Evdokimov A, Evrard E, Fonseca KR, Gan X, Ghosh S, Hayward MM, Horner W, Kim JY, McAllister LA, Pandit J, Paradis V, Parikh VD, Reese MR, Rong S, Salafia MA, Schuyten K, Strick CA, Tuttle JB, Valentine J, Wang H, Zawadzke LE, Verhoest PR., ACS Med. Chem. Lett. 3(3), 187-192

Nuclear hormone receptors
2006 - "Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.", Hopkins C.R., O'neil S.V., Laufersweiler M.C., Wang Y., Pokross M., Mekel M., Evdokimov A., Walter R., Kontoyianni M., Petrey M.E., Sabatakos G., Roesgen J.T., Richardson E., Demuth T.P. Jr., BMCL, 16(21), 5659-63.
[LINK][PDF]

Prolyl hydroxylases
2014 - "Prolyl hydroxylase inhibitors and methods of use", Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon ,US 20140057892
2008 - "Three dimensional coordinates of hypoxia inducible factor 1 alpha (HIF-1 alpha)-prolyl hydroxylase (EGLN1) and uses thereof", Evdokimov, A.G., Kawamoto, R.M., Boyer, A.S., Mekel, M.J., Pokross, M.E., Walter, R.L., United States Patent Application 20080124740
[LINK][PDF]
United States Patent Application 20080124740 2006 - "A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.", Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Evdokimov AG, Walter R, Mekel M. BMCL, 16(21), 5598-601.
[LINK][PDF]
2006 - "Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.", Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Zhou S, Winter C, Walter R, Mekel M, Evdokimov AG. BMCL, 16(21), 5517-22.
[LINK][PDF]
2006 - "Design and synthesis of a series of novel pyrazolopyridines as HIF 1-alpha prolyl hydroxylase inhibitors.", Warshakoon NC, Wu S, Boyer A, Kawamoto R, Renock S, Xu K, Pokross M, Evdokimov AG, Zhou S, Winter C, Walter R, Mekel M. BMCL, 16(21), 5687-90.
[LINK][PDF]
2006 - "Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.", Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Bhatt RT, Renock S, Xu K, Pokross M, Zhou S, Walter R, Mekel M, Evdokimov AG, East S. BMCL, 16(21), 5616-20.
[LINK][PDF]

Phosphatases & phosphodiesterases
2014 - "Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1", John M. Humphrey, Eddie Yang, Christopher W. am Ende, Eric P. Arnold, Jenna L. Head, Stephen Jenkinson, Lorraine A. Lebel, Spiros Liras, Jayvardhan Pandit, Brian Samas, Felix Vajdos, Samuel P. Simons, Artem Evdokimov, Mahmoud Mansour and Frank S. Menniti. Med. Chem. Commun, 5, 1290-1296.
2006 - "Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery", A. G. Evdokimov, M. Pokross, R. Walter, M. Mekel, B. Cox, C. Li, R. Bechard, F. Genbauffe, R. Andrews, C. Diven, B. Howard, V. Rastogi, J. Gray, M. Maier and K. G. Peters. Acta Cryst.D, 62, 1435-1445, 2006.
[LINK][PDF]
2006 - "Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.", Amarasinghe K.K., Evdokimov A.G., Xu K., Clark C.M., Maier M.B., Srivastava A., Colson A.O., Gerwe G.S., Stake G.E., Howard B.W., Pokross M.E., Gray J.L., Peters K.G. BMCL, 15;16(16):4252-6.
[LINK][PDF]
2006 - "1,2,3,4-tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors", S.R. Klopfenstein, A.G. Evdokimov, A.-O. Colson, N.T. Fairweather, J.J. Neuman, M.B. Maier, J.L. Gray, G.S. Gerwe, G.E. Stake, B.W. Howard, J.A. Farmer, M.E. Pokross, T.R. Downs, B.Kasibhatla, K.G.Peters., BMCL, 16(6):1574-1578, 2006.
[LINK][PDF]
2005 - "Tetrahydroisoquinolnyl sulfamic acids", Klopfenstein S.R., Maier M.B., Jones D.R., Gray J.L., Pokross M.E., Peters K.G., Evdokimov A.G., U.S. Pat. Appl. Publ. 2005, US20050154011.
2004 - "Three dimensional coordinates of HPTPbeta ", Evdokimov A.G., Pokross M.E., U.S. Pat. Appl. Publ. 2004, US20040077065.
2004 - "Phenethylamino sulfamic acids", Klopfenstein S.R., Maier M.B., Jones D.R., Gray J.L., Pokross M.E., Peters K.G., Evdokimov A.G., U.S. Pat. Appl. Publ. 2004, US20040167183 A120040826.
2003 - "Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component", Peters K.G., Davis M.G., Howard B.W., Pokross M., Rastogi V., Diven C., Greis K.D., Eby-Wilkens E., Maier M., Evdokimov A.G., Soper S., Genbauffe F., J. Inorg. Biochem. 2003 96(2-3), 321-30.
[LINK][PDF]


Site maintained by Artem Evdokimov